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. 1983 Sep 5;33(10):1001-6.
doi: 10.1016/0024-3205(83)90757-9.

Lead activates calmodulin sensitive processes

G W Goldstein, D Ar
Free article

Lead activates calmodulin sensitive processes

G W Goldstein et al. Life Sci. .
Free article

Abstract

The effect of lead on two calcium sensitive processes was determined. Micromolar concentrations of lead successfully replaced calcium in the activation of calmodulin-sensitive phosphodiesterase and in the promotion of potassium loss from erythrocytes. Both actions of lead were blocked by trifluoperazine--an inhibitor of calmodulin function. We propose that some of the toxic effects of lead may be explained by its interaction with calmodulin.

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