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. 1983 Aug;304(5928):699-703.
doi: 10.1038/304699a0.

Priming for and induction of anti-poliovirus neutralizing antibodies by synthetic peptides

E A Emini, B A Jameson, E Wimmer

Priming for and induction of anti-poliovirus neutralizing antibodies by synthetic peptides

E A Emini et al. Nature. 1983 Aug.

Abstract

Five peptides containing amino acid sequences from the type 1 poliovirus structural protein VP1 have been synthesized. Each of the peptides was found capable of priming the immune system of rabbits for a long-lasting, virus-neutralizing IgG antibody response following a single inoculation of intact virus. One peptide directly induced the production of neutralizing antibody.

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