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. 1983 Aug 25;11(16):5645-59.
doi: 10.1093/nar/11.16.5645.

The nucleotide sequence of replication and maintenance functions encoded by plasmid pSC101

G Churchward, P Linder, L Caro
Free PMC article

The nucleotide sequence of replication and maintenance functions encoded by plasmid pSC101

G Churchward et al. Nucleic Acids Res. .
Free PMC article

Abstract

The nucleotide sequence of 1100bp around the origin of replication of the pSC101 plasmid has been determined. This segment of DNA is capable of replication in the presence of a helper plasmid. The sequence data reveal similarities between pSC101 and several other replicons. The origin of replication contains three direct repeats of an 18bp sequence associated with a segment exceptionally rich in A-T base pairs. A promotor that probably directs transcription of a gene encoding an essential plasmid replication function is associated with a region of extensive potential secondary structure. The sequence presented here includes the sequence of the par region involved in partitioning of plasmids at cell division.

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References

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