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. 1983 Sep 10;11(17):5811-9.
doi: 10.1093/nar/11.17.5811.

Sequence of human haptoglobin cDNA: evidence that the alpha and beta subunits are coded by the same mRNA

G Raugei, G Bensi, V Colantuoni, V Romano, C Santoro, F Costanzo, R Cortese
Free PMC article

Sequence of human haptoglobin cDNA: evidence that the alpha and beta subunits are coded by the same mRNA

G Raugei et al. Nucleic Acids Res. .
Free PMC article

Abstract

We have isolated and sequenced a cDNA clone coding for human haptoglobin. Our sequence shows that haptoglobin is very likely synthesized as a single polypeptide chain which is then cleaved at an Arg residue to generate its two characteristic alpha and beta subunit. Southern blot analysis suggests that there are at least two copies of the haptoglobin gene per haploid genome.

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References

    1. Adv Hum Genet. 1982;12:189-261, 453-4 - PubMed
    1. Nature. 1963 Feb 9;197:576-7 - PubMed
    1. Proc Natl Acad Sci U S A. 1982 Nov;79(21):6461-4 - PubMed
    1. Nucleic Acids Res. 1983 Mar 25;11(6):1645-55 - PubMed
    1. Nature. 1983 May 26;303(5915):300-7 - PubMed

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