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. 1983 Sep 10;11(17):5953-67.
doi: 10.1093/nar/11.17.5953.

High spontaneous mutation rate of Rous sarcoma virus demonstrated by direct sequencing of the RNA genome

J L Darlix, P F Spahr
Free PMC article

High spontaneous mutation rate of Rous sarcoma virus demonstrated by direct sequencing of the RNA genome

J L Darlix et al. Nucleic Acids Res. .
Free PMC article

Abstract

Direct and extensive sequencing of RSV RNA genome is reported. More than 10,000 nt of the T1 RNase resistant RSV RNA fragments (1) have been sequenced and shown to cover 3900 nt of RSV genome. The frequent sequence variations found indicate that RSV supports a very high incidence of spontaneous mutations in the course of replication, one very probable cause of the genetic diversity among the avian retroviruses. Sequences of the structured RSV RNAs allowed us also to precisely characterize the structured domains of the retroviral genome and show that the src gene is not structured.

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References

    1. Cell. 1983 Mar;32(3):853-69 - PubMed
    1. Nucleic Acids Res. 1982 Dec 11;10(23):7461-75 - PubMed
    1. Virology. 1971 Dec;46(3):939-46 - PubMed
    1. Virology. 1972 Jul;49(1):37-44 - PubMed
    1. Anal Biochem. 1972 Sep;49(1):184-97 - PubMed

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