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. 1983 Oct;80(19):6101-4.
doi: 10.1073/pnas.80.19.6101.

Ouabain-like activity in human cerebrospinal fluid

J Halperín, R Schaeffer, L Galvez, S Malavé

Ouabain-like activity in human cerebrospinal fluid

J Halperín et al. Proc Natl Acad Sci U S A. 1983 Oct.

Abstract

Human cerebrospinal fluid has been found to mimic the effect of ouabain on net Na+ efflux and 86Rb+ influx across erythrocyte membranes and on the in vitro activity of a purified Na+/K+-ATPase (ATP phosphohydrolase, EC 3.6.1.3) derived from canine kidney. These results indicate the possible existence in human cerebrospinal fluid of an endogenous factor with ouabain-like activity, which might be linked to sodium metabolism.

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