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. 1983 Sep 16;221(4616):1181-3.
doi: 10.1126/science.6310748.

1,25-dihydroxyvitamin D3 receptors in human leukocytes

D M Provvedini, C D Tsoukas, L J Deftos, S C Manolagas

1,25-dihydroxyvitamin D3 receptors in human leukocytes

D M Provvedini et al. Science. .

Abstract

A 1,25-dihydroxyvitamin D3 receptor macromolecule was detected in peripheral mononuclear leukocytes from normal humans. This macromolecule was found to be present in monocytes but absent from normal resting peripheral B and T lymphocytes. However, it was present in established lines of malignant B, T, and non-B, non-T human lymphocytes, as well as in T and B lymphocytes obtained from normal humans and activated in vitro.

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