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Clinical Trial
. 1983 Jul:12 Suppl A:93-9.
doi: 10.1093/jac/12.suppl_a.93.

Randomized study of ceftazidime versus gentamicin plus cefotaxime for infections in severe granulocytopenic patients

Clinical Trial

Randomized study of ceftazidime versus gentamicin plus cefotaxime for infections in severe granulocytopenic patients

B E de Pauw et al. J Antimicrob Chemother. 1983 Jul.

Abstract

A randomized study of gentamicin plus cefotaxime versus ceftazidime alone was performed in 87 patients, with a neutrophil count of less than 1000/mm3 at the start of the treatment. The overall cure rate for the ceftazidime group was 71% and for the gentamicin plus cefotaxime 47%. This difference was shown to be statistically significant at a level of P less than 0.05. The cure rates for the microbiologically proven infections were 90 and 63% respectively. Serious adverse effects, causing preliminary withdrawal of therapy, have not been observed.

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