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. 1983 Sep;47(3):649-51.
doi: 10.1128/JVI.47.3.649-651.1983.

Murine retroviral restriction genes Fv-4 and Akvr-1 are alleles of a single locus

S J O'Brien, E J Berman, J D Estes, M B Gardner

Murine retroviral restriction genes Fv-4 and Akvr-1 are alleles of a single locus

S J O'Brien et al. J Virol. 1983 Sep.

Abstract

The two murine retroviral restriction genes, Fv-4 and Akvr-1, are very similar in their effects, distributions, ranges of action, and phenotypes. Akvr-1 has been shown to segregate independently in backcrosses with a variety of retroviral restriction loci, including Fv-1, Fv-2, Ril-1, and Ril-2. An allelism test cross of FRG (Fv-4R) X LCRR (Akvr-1R) hybrids mated to AKR mice failed to produce any viremic offspring. These results suggested that Akvr-1R and Fv-4R are alleles of a single locus, Fv-4, on mouse chromosome 12.

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