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Comparative Study
. 1983 Oct;305(5935):605-8.
doi: 10.1038/305605a0.

Structural and immunological similarities between simian sarcoma virus gene product(s) and human platelet-derived growth factor

K C Robbins, H N Antoniades, S G Devare, M W Hunkapiller, S A Aaronson
Comparative Study

Structural and immunological similarities between simian sarcoma virus gene product(s) and human platelet-derived growth factor

K C Robbins et al. Nature. 1983 Oct.

Abstract

The predicted amino acid sequence of the simian sarcoma virus (SSV) transforming gene product, p28sis, closely corresponds to that of human platelet-derived growth factor (PDGF). We demonstrate that p28sis rapidly undergoes a series of discrete processing steps including dimer formation and proteolytic digestion to yield molecules structurally and immunologically resembling biologically active PDGF.

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