Review
doi: 10.1126/science.6314503.
Modulation of synapse formation by cyclic adenosine monophosphate
- PMID: 6314503
- DOI: 10.1126/science.6314503
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Review
Modulation of synapse formation by cyclic adenosine monophosphate
Science.
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Abstract
Synapses between neuroblastoma-hybrid cells and myotubes exhibit a high degree of plasticity. Increase of cyclic adenosine monophosphate (AMP) levels of the hybrid cells for several days results in the appearance of functional voltage-sensitive Ca2+ channels, which are required for evoked secretion of acetylcholine. The results show that cyclic AMP regulates synaptogenesis by regulating the expression of voltage-sensitive Ca2+ channels, and suggest that cyclic AMP affects posttranslational modifications of some glycoproteins and cellular levels of certain proteins.
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