Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1983 Dec 9;222(4628):1125-7.
doi: 10.1126/science.6316502.

Productive infection and cell-free transmission of human T-cell leukemia virus in a nonlymphoid cell line

P Clapham, K Nagy, R Cheingsong-Popov, M Exley, R A Weiss

Productive infection and cell-free transmission of human T-cell leukemia virus in a nonlymphoid cell line

P Clapham et al. Science. .

Abstract

Human T-cell leukemia virus (HTLV), American PL isolate, was transmitted by cocultivation and by cell-free filtrates to a nonlymphoid human osteogenic sarcoma (HOS) cell line, designated HOS/PL, but not to nine other lines bearing receptors for HTLV. HOS and HOS/PL cells are not dependent on interleukin-2 and do not express interleukin-2 receptors that are recognized by anti-Tac monoclonal antibody. HTLV released by the Japanese MT2 cell line was also transmitted to HOS cells. The infected HOS cells release substantial titers of progeny HTLV which is antigenically indistinguishable from parental virus and is able to transform T cells.

PubMed Disclaimer

Publication types

LinkOut - more resources