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. 1983 Nov 25;95(3-4):287-90.
doi: 10.1016/0014-2999(83)90648-9.

Dissociation of presynaptic alpha 2-adrenoceptors following prazosin administration: presynaptic effect of prazosin

E S Vizi, N Ludvig, A Z Rónai, G Folly

Dissociation of presynaptic alpha 2-adrenoceptors following prazosin administration: presynaptic effect of prazosin

E S Vizi et al. Eur J Pharmacol. .

Abstract

Evidence has been obtained that prazosin possesses a presynaptic alpha 2-adrenoceptor blocking action in the rat was deferens preparation stimulated at 1 Hz. In the presence of prazosin yohimbine failed to affect the presynaptic alpha 2-adrenoceptor stimulatory effect of 1-noradrenaline while the effect of xylazine was almost completely abolished. It is therefore suggested that there are two kinetically different prejunctional alpha 2-adrenoceptor sites.

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