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Comparative Study
. 1983 Dec;19(3):293-7.
doi: 10.1016/0378-4274(83)90133-9.

Rat liver microsomal transformation of ethene to oxirane in vitro

G Schmiedel, J G Filser, H M Bolt
Comparative Study

Rat liver microsomal transformation of ethene to oxirane in vitro

G Schmiedel et al. Toxicol Lett. 1983 Dec.

Abstract

Rat liver microsomal monooxygenases transform ethene to oxirane. Compared with 1,3-butadiene, which is metabolized to vinyl oxirane, this transformation proceeds more slowly. Also, oxirane has a distinctly lower alkylating potency than vinyloxirane towards the test reagent (p-nitrobenzyl)-pyridine. This may suggest a lower toxicity of ethene, compared with butadiene.

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