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. 1983 Nov 30;117(1):114-21.
doi: 10.1016/0006-291x(83)91548-6.

Isolation and characterization of a human interleukin 2 gene

S Mita, S Maeda, K Obaru, N Nishino, K Shimada, T Hirano, K Onoue, T Ogawa, H Ogawa

Isolation and characterization of a human interleukin 2 gene

S Mita et al. Biochem Biophys Res Commun. .

Abstract

An interleukin 2 (IL-2) gene was isolated from a Charon 4A human gene library. Electron microscopic examination of 15 heteroduplexes formed between the genomic DNAs and the IL-2 cDNAs demonstrated that the size of the IL-2 gene is about 5.1 +/- 0.5 kb and that there are at least two introns in this gene. Nucleotide sequence of the 5' flanking region of the IL-2 gene showed a homology with that of the corresponding region of the human immune interferon gene.

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