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. 1983:33 Suppl 1:409-11.
doi: 10.1016/0024-3205(83)90529-5.

Circadian rhythms and levels of beta-endorphin, ACTH, and cortisol during chronic methadone maintenance treatment in humans

M J Kreek, S L Wardlaw, N Hartman, J Raghunath, J Friedman, B Schneider, A G Frantz

Circadian rhythms and levels of beta-endorphin, ACTH, and cortisol during chronic methadone maintenance treatment in humans

M J Kreek et al. Life Sci. 1983.

Abstract

Previous studies have shown alterations of neuroendocrine function in humans receiving any narcotic on short-term basis or short-acting narcotics on a chronic basis. In this study of 16 well-stabilized patients, it was demonstrated that normalization of hypothalamic-pituitary-adrenal axis function, as reflected by normal levels and normal circadian rhythm of levels of beta-endorphin, ACTH and cortisol, is achieved during long-term steady state methadone maintenance treatment of former heroin addicts.

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