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. 1984 Feb;307(5952):604-8.
doi: 10.1038/307604a0.

Expression of functional acetylcholine receptor from cloned cDNAs

M Mishina, T Kurosaki, T Tobimatsu, Y Morimoto, M Noda, T Yamamoto, M Terao, J Lindstrom, T Takahashi, M Kuno, et al.

Expression of functional acetylcholine receptor from cloned cDNAs

M Mishina et al. Nature. 1984 Feb.

Abstract

The cloned cDNAs encoding the four subunits of the Torpedo californica acetylcholine receptor, each carried by a simian virus 40 vector, direct the synthesis of the functional receptor in a combined expression system consisting of COS monkey cells and Xenopus oocytes. Our results suggest that all four subunits are required to elicit a normal nicotinic response to acetylcholine, whereas only the alpha-subunit is indispensable for alpha-bungarotoxin binding activity.

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