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. 1984 Feb;307(5952):609-13.
doi: 10.1038/307609a0.

Two configurations of a channel-forming membrane protein

P N Unwin, P D Ennis

Two configurations of a channel-forming membrane protein

P N Unwin et al. Nature. 1984 Feb.

Abstract

The protein oligomer forming the gap junction channel has been analysed in two Ca2+-sensitive states by electron microscopy of membranes in frozen aqueous solutions. Switching between states occurs by a small cooperative rearrangement involving tilting of the subunits, which may be responsible for the effect of Ca2+ on channel permeability in vivo.

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