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. 1984 Feb;175(2):243-50.
doi: 10.3181/00379727-175-41796.

HCMV envelope antigens induce both humoral and cellular immunity in guinea pigs

T Furukawa, E Gonczol, S Starr, M D Tolpin, A Arbeter, S A Plotkin

HCMV envelope antigens induce both humoral and cellular immunity in guinea pigs

T Furukawa et al. Proc Soc Exp Biol Med. 1984 Feb.

Abstract

Antibody and cellular immunity were measured in guinea pigs immunized with whole virion, with nucleocapsids of human cytomegalovirus or with solubilized antigens containing virus envelope proteins. All the three types of immunogens induced the production of humoral antibody as well as cytomegalovirus (CMV)-specific cellular immunity. In immunization experiments envelope antigen was as effective as immunization with whole virion.

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