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. 1984;54(1):191-4.
doi: 10.1007/BF00235831.

Reduced spinal reflexes following intrathecal baclofen in the rabbit

J S Kroin, R D Penn, R L Beissinger, R C Arzbaecher

Reduced spinal reflexes following intrathecal baclofen in the rabbit

J S Kroin et al. Exp Brain Res. 1984.

Abstract

Intrathecal baclofen is effective in reducing polysynaptic spinal reflexes in awake rabbits. A single lumbar infusion of 2.5-5.0 ng drug caused a significant reduction in the crossed extensor response to electrical stimulation of the plantar surface of the hindlimb. This inhibition lasted 5 h or more. At doses of 3 micrograms or less, the forelimbs were unaffected.

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