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Comparative Study
. 1984 Jan;23(1):42-6.
doi: 10.1111/j.1399-3011.1984.tb02690.x.

Adrenocorticotropin. 57. Synthesis and biological activity of ostrich and turkey hormones

D Yamashiro, C L Ho, C H Li
Comparative Study

Adrenocorticotropin. 57. Synthesis and biological activity of ostrich and turkey hormones

D Yamashiro et al. Int J Pept Protein Res. 1984 Jan.

Abstract

Synthesis of ostrich and turkey corticotropin (ACTH) has been accomplished by the solid-phase method. Each was identical to the natural hormone in high performance liquid chromatography. Relative potencies in a lipolytic assay in isolated rabbit fat cells were: human ACTH, 100; ostrich ACTH, 53; turkey ACTH, 28. In isolated rat fat cells relative lipolytic potencies were: human ACTH, 100; ostrich ACTH, 2; turkey ACTH, 13. It was concluded that lipolytic potency is sensitive to alterations in structure throughout the entire length of the ACTH sequence in the rat fat cell assay.

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