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. 1984;21(1):25-37.
doi: 10.1159/000149500.

Variation in the structure of varicella-zoster virus DNA

Variation in the structure of varicella-zoster virus DNA

J R Ecker et al. Intervirology. 1984.

Abstract

By analyzing the fine structure of varicella-zoster virus (VZV) DNA, a naturally occurring heterogeneity was found on the right end of VZV DNA, but no evidence of a true terminal repetition was uncovered. We were unable to confirm the report of Straus and co-workers (1981) that there is a relatively high frequency of circular VZV DNA in low-passage virus. On long-term cell passage, extensive heterogeneity appeared concomitant with the accumulation of apparently defective VZV DNA.

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