doi: 10.1016/0306-9877(83)90042-7.
The Na,K-ATPase hypothesis for manic-depression. I. General considerations
- PMID: 6321918
- DOI: 10.1016/0306-9877(83)90042-7
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The Na,K-ATPase hypothesis for manic-depression. I. General considerations
Med Hypotheses.
1983 Nov.
Abstract
An hypothesis is presented to explain and integrate experimental and clinical observations on manic-depressive (bipolar or biphasic) psychosis. The model is based on alterations in the activity of the sodium, potassium-activated adenosine triphosphatase (Na, K-ATPase) pump. A reduction in the activity of the Na,K-ATPase can be responsible for both phases of the disorder.
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