Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1983 Nov;12(3):253-68.
doi: 10.1016/0306-9877(83)90042-7.

The Na,K-ATPase hypothesis for manic-depression. I. General considerations

R S el-Mallakh

The Na,K-ATPase hypothesis for manic-depression. I. General considerations

R S el-Mallakh. Med Hypotheses. 1983 Nov.

Abstract

An hypothesis is presented to explain and integrate experimental and clinical observations on manic-depressive (bipolar or biphasic) psychosis. The model is based on alterations in the activity of the sodium, potassium-activated adenosine triphosphatase (Na, K-ATPase) pump. A reduction in the activity of the Na,K-ATPase can be responsible for both phases of the disorder.

PubMed Disclaimer

Publication types

LinkOut - more resources