doi: 10.1016/0306-9877(83)90043-9.
The Na,K-ATPase hypothesis for manic-depression. II. The mechanism of action of lithium
- PMID: 6321919
- DOI: 10.1016/0306-9877(83)90043-9
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The Na,K-ATPase hypothesis for manic-depression. II. The mechanism of action of lithium
Med Hypotheses.
1983 Nov.
Abstract
A model as to how lithium may work in the treatment and prevention of manic-depression is presented. Lithium accumulates intracellularly, and accumulates preferentially in more active neurons. Intracellular accumulation of lithium displaces intracellular sodium, which, in turn, decreases intracellular calcium. A decrease of intracellular calcium normalizes neuron activity in both mania and depression. This model is supported by the majority of clinical and experimental data.
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