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. 1984 Mar;308(5954):32-6.
doi: 10.1038/308032a0.

Cryo-electron microscopy of viruses

M Adrian, J Dubochet, J Lepault, A W McDowall
Free article

Cryo-electron microscopy of viruses

M Adrian et al. Nature. 1984 Mar.
Free article

Abstract

Thin vitrified layers of unfixed, unstained and unsupported virus suspensions can be prepared for observation by cryo-electron microscopy in easily controlled conditions. The viral particles appear free from the kind of damage caused by dehydration, freezing or adsorption to a support that is encountered in preparing biological samples for conventional electron microscopy. Cryo-electron microscopy of vitrified specimens offers possibilities for high resolution observations that compare favourably with any other electron microscopical method.

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