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Comparative Study
. 1984 Feb 10;12(3):1687-96.
doi: 10.1093/nar/12.3.1687.

Evolutionary conservation in the untranslated regions of actin mRNAs: DNA sequence of a human beta-actin cDNA

P Ponte, S Y Ng, J Engel, P Gunning, L Kedes
Free PMC article
Comparative Study

Evolutionary conservation in the untranslated regions of actin mRNAs: DNA sequence of a human beta-actin cDNA

P Ponte et al. Nucleic Acids Res. .
Free PMC article

Abstract

We report the complete nucleotide sequence of a human beta actin cDNA. Both the 5' and 3' untranslated regions of the sequence are similar (greater than 80%) to the analogous regions of the rat beta-actin gene reported by Nudel et al (1983). When a segment of the 3' untranslated region is used as a radiolabelled probe, strong hybridization to chick beta actin mRNA is seen. This conservation of sequences suggests that strong selective pressures operate on non-translated segments of beta actin mRNA.

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References

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