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. 1984 Mar 23;223(4642):1299-301.
doi: 10.1126/science.6322300.

Total synthesis and cloning of a gene coding for the ribonuclease S protein

K P Nambiar, J Stackhouse, D M Stauffer, W P Kennedy, J K Eldredge, S A Benner

Total synthesis and cloning of a gene coding for the ribonuclease S protein

K P Nambiar et al. Science. .

Abstract

A gene for ribonuclease S protein, has been chemically synthesized and cloned. The gene is designed to have 25 specific restriction endonuclease sites spaced at short intervals, permitting its structure to be rapidly modified. This flexibility facilitates tests of hypotheses relating the primary structure of the enzyme to its physical and catalytic behavior.

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