doi: 10.1016/0042-6822(84)90442-2.
Lack of correlation between thymidine kinase activity and the antiviral or antiproliferative response to interferon
- PMID: 6322432
- DOI: 10.1016/0042-6822(84)90442-2
Item in Clipboard
Lack of correlation between thymidine kinase activity and the antiviral or antiproliferative response to interferon
Virology.
1984 Feb.
Abstract
Murine L cells lacking thymidine kinase activity (Ltk-) do not respond to the antiviral or antiproliferative activity of interferon, whereas human tk- cells show a normal response. Furthermore, a clone of tk+ cells derived from Ltk- cells by DNA-mediated transfer of the tk herpes gene does not respond to interferon. Cells of this clone and Ltk- cells do not produce interferon when infected with Newcastle disease virus or treated with poly(I) X poly(C) and DEAE-dextran. Possible reasons for this inability to produce interferon and the lack of response to interferon are discussed.
Similar articles
-
Induction of an anti-viral response and 2',5'-oligo A synthetase by interferon in several thymidine kinase-deficient cell lines.Virology. 1984 Mar;133(2):464-9. doi: 10.1016/0042-6822(84)90415-x. Virology. 1984. PMID: 6324463
-
Induction of an antiviral response by interferon requires thymidine kinase.Proc Natl Acad Sci U S A. 1983 Jan;80(1):26-30. doi: 10.1073/pnas.80.1.26. Proc Natl Acad Sci U S A. 1983. PMID: 6185957 Free PMC article.
-
The effect of interferon on cells deficient in nucleoside transport or lacking thymidine kinase activity.Biochem Biophys Res Commun. 1984 Jan 13;118(1):124-30. doi: 10.1016/0006-291x(84)91076-3. Biochem Biophys Res Commun. 1984. PMID: 6696750
-
Inhibition by interferon of herpes simplex virus thymidine kinase and DNA polymerase in infected and biochemically transformed cells.J Gen Virol. 1983 Sep;64 (Pt 9):1999-2006. doi: 10.1099/0022-1317-64-9-1999. J Gen Virol. 1983. PMID: 6193244
-
Thymidine kinase gene transfer by herpes simplex virus.Bull Cancer. 1976 Jul-Sep;63(3):393-8. Bull Cancer. 1976. PMID: 187268 Review.
Cited by
-
Biologic agents as biochemical modulators: pharmacologic basis for the interaction of cytotoxic chemotherapeutic drugs and interferon.Cancer Chemother Pharmacol. 1994;35(1):21-30. doi: 10.1007/BF00686280. Cancer Chemother Pharmacol. 1994. PMID: 7527304 Review.