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. 1984 Feb 14;118(3):842-7.
doi: 10.1016/0006-291x(84)91471-2.

Enhancement of calcium influx in human platelets by CGP 28392, a novel dihydropyridine

P Erne, E Bürgisser, F R Bühler, B Dubach, H Kühnis, M Meier, H Rogg

Enhancement of calcium influx in human platelets by CGP 28392, a novel dihydropyridine

P Erne et al. Biochem Biophys Res Commun. .

Abstract

CGP 28392, a novel compound structurally related to the dihydropyridine Ca2+-entry blockers, causes a dose-dependent increase in intracellular free Ca2+ in human platelets, as measured with the Quin-2 Ca2+ indicator, with a semimaximal effective concentration of 2.2 X 10(-7) M. This effect occurs in a concentration range in which CGP 28392 competes for specific [3H]nitrendipine binding in guinea pig heart membranes. It can be inhibited by nitrendipine. The data presented furnish direct evidence of the Ca2+-entry-stimulating properties of CGP 28392 and indicate the presence of dihydropyridine-susceptible structures in human platelets.

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