[Comparative studies on fibrogenic properties of diatomites and other silica dusts]

Abstract

The experiment carried out on animals was aimed at testing fibrogenic properties of two samples of the Carpathian diatomites and silica earth from Piotrowice. Experimental pneumoconiosis was induced by intratracheal administration of 50 mg of dust suspended in 0,6 ml of NaCl physiological solution to experimental animals (rats). The animals were killed after 3,6 and 9 months since dust administration and the examinations consisted in determination of wet lungs weight, hydroxyproline content in lungs, mediastinum nodes weight and lipids content. Comparison of the achieved results indicated that diatomites fibrogenic properties are many times lower than fibrogenic properties of silica earth. This fact, at similar physico-chemical properties of these raw materials, creates a possibility of elimination of workers exposure to highly aggressive silica earth dust by replacing it by diatomite.