Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1984;308(5958):421-4.
doi: 10.1038/308421a0.

Messenger RNA from human brain induces drug- and voltage-operated channels in Xenopus oocytes

C B Gundersen, R Miledi, I Parker

Messenger RNA from human brain induces drug- and voltage-operated channels in Xenopus oocytes

C B Gundersen et al. Nature. 1984.

Abstract

Sodium channels and receptors to serotonin and kainate were 'transplanted' from human brain into frog oocytes, by isolating messenger RNA from a fetal brain, and injecting it into Xenopus laevis oocytes. The mRNA was translated by the oocyte and induced the appearance of functional receptors and channels in its membrane. This approach renders drug- and voltage-operated channels of the human brain more amenable to detailed study.

PubMed Disclaimer

Publication types

LinkOut - more resources