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. 1984 Mar;81(5):1389-90.
doi: 10.1073/pnas.81.5.1389.

beta-endorphin-(1-27) is an antagonist of beta-endorphin analgesia

R G Hammonds Jr, P Nicolas, C H Li

beta-endorphin-(1-27) is an antagonist of beta-endorphin analgesia

R G Hammonds Jr et al. Proc Natl Acad Sci U S A. 1984 Mar.

Abstract

beta h-Endorphin-(1-27), a naturally occurring fragment of human beta-endorphin (beta h-endorphin), diminishes the analgesic effect of beta h-endorphin when coinjected intra-cerebroventricularly into mice. A parallel shift in the dose-response curve of beta h-endorphin in the presence of beta h-endorphin-(1-27) suggests competition at the same site. The potency of beta h-endorphin-(1-27) in antagonizing analgesia is greater than 4 times greater than that of the opiate antagonist naloxone.

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