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. 1983 Dec;3(4):345-53.
doi: 10.1007/BF00734715.

Cyclic AMP enhances calcium-dependent potassium current in Aplysia neurons

D Ewald, R Eckert

Cyclic AMP enhances calcium-dependent potassium current in Aplysia neurons

D Ewald et al. Cell Mol Neurobiol. 1983 Dec.

Abstract

The effect on the Ca-dependent potassium current, IK(Ca), of procedures that increase intracellular cAMP levels was studied in Aplysia neurons using three different pharmacological approaches. Exposure to cAMP analogues which were either resistant to or protected from phosphodiesterase hydrolysis caused an increase in IK(Ca) from 30 to 50% in 10 min. The degree of reversibility of this effect varied from complete with db cAMP to very little with pcpt cAMP. Exposure to cholera toxin, which stimulates the synthesis of endogenous cAMP, increased IK(Ca) 25% in 10 min and the effect was not reversible. Both approaches were effective in all seven neuron types studied. Application of serotonin plus phosphodiesterase inhibitor caused an increase in IK(Ca) in neuron R15 but not in the other neuron types. Application of pentylene tetrazole (PTZ) led to a decrease in IK(Ca). It is proposed that elevation of cyclic AMP mediates an increased sensitivity of the IK(Ca) channel to Ca ions.

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References

    1. Adams, W. B., and Levitan, I. B. (1982). Intracellular injection of protein kinase inhibitor blocks the serotonin-induced increase in K+ conductance inAplysia neuron R15.Proc. Natl. Acad. Sci. USA793877–3880. - PMC - PubMed
    1. Benson, J. A., and Levitan, I. B. (1983). Serotonin-increases an anomalously rectifying K+ current in theAplysia neuron R15.Proc. Natl. Acad. Sci. USA803522–3525. - PMC - PubMed
    1. Cedar, H., and Schwartz, J. H. (1972). Cyclic adenosine monophosphate in the nervous system ofAplysia californica II. Effect of serotonin and dopamine.J. Gen. Physiol.60570–587. - PMC - PubMed
    1. de Peyer, J. E., Cachelin, A. B., Levitan, I. B., and Reuter, H. (1982). Ca2+-activated K+ conductance in internally perfused snail neurons is enhanced by protein phosphorylation.Proc. Natl. Acad. Sci. USA794207–4211. - PMC - PubMed
    1. Deterre, P., Paupardin-Tritsch, D., Bockaert, J., and Gershenfeld, H. M. (1981). Role of cyclic AMP in a serotonin-evoked slow inward current in snail neurons.Nature290783–785. - PubMed

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