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Comparative Study
. 1984 Apr;4(4):755-60.
doi: 10.1128/mcb.4.4.755-760.1984.

Polyoma middle T antigen requires cooperation from another gene to express the malignant phenotype in vivo

C Asselin, C Gélinas, P E Branton, M Bastin
Comparative Study

Polyoma middle T antigen requires cooperation from another gene to express the malignant phenotype in vivo

C Asselin et al. Mol Cell Biol. 1984 Apr.

Abstract

The oncogenic potential of polyomavirus in newborn hamsters can be expressed by a recombinant encoding only the middle T protein. However, polyoma middle T requires the cooperation from small T to induce tumors in newborn rats. Similar complementary functions such as cocarcinogens or tumor promotors can be exerted by the simian virus 40 T antigens as well as by one or several products of the early region 1A of adenovirus 2.

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References

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    1. Nature. 1981 Aug 13;292(5824):595-600 - PubMed
    1. Proc Natl Acad Sci U S A. 1982 Sep;79(17):5189-93 - PubMed
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