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. 1984 Apr;81(7):2097-101.
doi: 10.1073/pnas.81.7.2097.

Proviruses are adjacent to c-myc in some murine leukemia virus-induced lymphomas

D Steffen

Proviruses are adjacent to c-myc in some murine leukemia virus-induced lymphomas

D Steffen. Proc Natl Acad Sci U S A. 1984 Apr.

Abstract

Sixty-one murine leukemia virus-induced lymphomas were examined for evidence of proviral insertions adjacent to known oncogenes. Five of these lymphomas were found to have alterations adjacent to c-myc. Two of the lymphomas with altered c-myc sequences were examined in detail. Evidence was obtained showing that the alterations in the c-myc sequences in these two lymphomas were the result of proviral integrations. This result suggests that lymphomagenesis by murine leukemia viruses can result from insertional mutagenesis of cellular oncogenes.

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