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. 1984 May;158(2):665-73.
doi: 10.1128/jb.158.2.665-673.1984.

D-ribose metabolism in Escherichia coli K-12: genetics, regulation, and transport

J E Lopilato, J L Garwin, S D Emr, T J Silhavy, J R Beckwith

D-ribose metabolism in Escherichia coli K-12: genetics, regulation, and transport

J E Lopilato et al. J Bacteriol. 1984 May.

Abstract

We have isolated mutants defective in high-affinity D-ribose transport. The mutations map in rbsT or rbsB , the structural gene for ribose binding protein. rbsT consists of at least one gene coding for a protein required for high-affinity transport. The high-affinity transport-defective mutants were able to utilize D-ribose, indicating that at least a second, low-affinity transport system for D-ribose is present in Escherichia coli K-12. rbsT and rbsB are located at min 84 on the E. coli genetic map and, together with rbsK , the gene coding for ribokinase , constitute an rbs operon. The order of genes is rbsP /O rbsT rbsB rbsK . The rbs operon is subject to negative control by the product of the rbsR gene. rbsR is located distal to the rbs operon and appears to form a separate transcriptional unit.

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