doi: 10.1038/309322a0.
Somatic recombination in a murine T-cell receptor gene
- PMID: 6328306
- DOI: 10.1038/309322a0
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Somatic recombination in a murine T-cell receptor gene
Nature.
1984 May.
Abstract
A putative T-cell receptor gene was isolated from the DNA of the helper hybridoma, 2B4 . Analysis of the sequence components of this rearranged gene indicates the presence of separate variable (V), diversity (D) and joining (J) region elements analogous to those of heavy-chain immunoglobulins. These findings further support the belief that the products of this locus are involved in antigen recognition by T cells. There is no evidence of somatic mutation between the putative germ-line and the expressed variable-region gene.
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