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. 1984 Jun;309(5970):677-81.
doi: 10.1038/309677a0.

Reverse gyrase--a topoisomerase which introduces positive superhelical turns into DNA

A Kikuchi, K Asai

Reverse gyrase--a topoisomerase which introduces positive superhelical turns into DNA

A Kikuchi et al. Nature. 1984 Jun.

Abstract

An enzymatic activity which converts closed circular DNA into a positively supercoiled form is present in cellular extracts of Sulfolobus, an acidothermophilic archaebacterium. This novel enzyme is a type II DNA topoisomerase and is active only at temperatures greater than 55 degrees C, in the presence of ATP and Mg2+.

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