Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1984 May 25;12(10):4295-311.
doi: 10.1093/nar/12.10.4295.

The TGGCA-binding protein: a eukaryotic nuclear protein recognizing a symmetrical sequence on double-stranded linear DNA

U Borgmeyer, J Nowock, A E Sippel
Free PMC article

The TGGCA-binding protein: a eukaryotic nuclear protein recognizing a symmetrical sequence on double-stranded linear DNA

U Borgmeyer et al. Nucleic Acids Res. .
Free PMC article

Abstract

Low salt extracts of chicken oviduct nuclei contain a DNA binding protein with high affinity for specific DNA sequences in the flanking regions of the chicken lysozyme gene. Two of the three binding sites found within a total of 11 kb upstream from the promoter are located only 92 bp apart from each other. Upon comparison of the DNA binding sites, the symmetrical consensus sequence 5'- TGGCANNNTGCCA -3' can be deduced as the protein recognition site. This sequence is the central part of 23 to 25 base pairs protected by the DNA binding protein from DNAase I digestion. A homologous binding activity can be detected in nuclei from several chicken tissues and from mouse liver.

PubMed Disclaimer

References

    1. Cell. 1977 Aug;11(4):923-32 - PubMed
    1. Nucleic Acids Res. 1976 Sep;3(9):2387-98 - PubMed
    1. Cold Spring Harb Symp Quant Biol. 1978;42 Pt 1:57-75 - PubMed
    1. Nucleic Acids Res. 1978 Sep;5(9):3157-70 - PubMed
    1. Biochemistry. 1979 Feb 20;18(4):616-24 - PubMed

Publication types

Associated data