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. 1984 Jun;81(12):3838-42.
doi: 10.1073/pnas.81.12.3838.

Goodpasture antigen of the glomerular basement membrane: localization to noncollagenous regions of type IV collagen

J Wieslander, J F Barr, R J Butkowski, S J Edwards, P Bygren, D Heinegård, B G Hudson

Goodpasture antigen of the glomerular basement membrane: localization to noncollagenous regions of type IV collagen

J Wieslander et al. Proc Natl Acad Sci U S A. 1984 Jun.

Abstract

The glomerular basement membrane antigen in Goodpasture syndrome is a collagenase-resistant molecule with a monomer molecular weight of about 26,000. Type IV collagen isolated from glomerular basement membrane contains collagenase-resistant sequences within its structure. Polyacrylamide gel electrophoresis, enzyme-linked immunosorbent assay, and chemical analysis were used to demonstrate that the collagenase-resistant sequences of type IV collagen contain Goodpasture antigen.

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