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. 1984 Apr;25(4):524-6.
doi: 10.1128/AAC.25.4.524.

Phosphorylation of four acyclic guanosine analogs by herpes simplex virus type 2 thymidine kinase

A Larsson, P Z Tao

Phosphorylation of four acyclic guanosine analogs by herpes simplex virus type 2 thymidine kinase

A Larsson et al. Antimicrob Agents Chemother. 1984 Apr.

Abstract

Four acyclic guanosine analogs, the (R) and (S) enantiomers of 9-(3,4-dihydroxybutyl)guanine, 9-(4-hydroxybutyl)guanine, and acyclovir were compared in enzyme kinetic experiments, using purified herpes simplex virus type 2 thymidine kinase. All four analogs showed competitive patterns of inhibition in the phosphorylation of thymidine by the viral thymidine kinase, but different affinities and relative rates of phosphorylation were observed.

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