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. 1984 Apr 6;99(4):353-6.
doi: 10.1016/0014-2999(84)90146-8.

Inappropriate correction for radioactive decay in fully iodinated adrenergic radioligands

V M Doyle, F R Bühler, E Bürgisser

Inappropriate correction for radioactive decay in fully iodinated adrenergic radioligands

V M Doyle et al. Eur J Pharmacol. .

Abstract

The present data demonstrate increased binding of various iodinated adrenergic radioligands. In contrast, this was not observed for [3H]dihydroalprenolol. This systematic deviation of apparent binding parameters can be explained by the inappropriate use of a decay correction factor, indicating that the decayed iodinated radioligands lose their binding ability. Consequently no correction for decay is required in the case of iodinated adrenergic radioligands.

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