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. 1984 Jul;159(1):381-4.
doi: 10.1128/jb.159.1.381-384.1984.

Regulation of a macrolide resistance-beta-galactosidase (ermC-lacZ) gene fusion in Escherichia coli

D R Kirsch, M H Lai

Regulation of a macrolide resistance-beta-galactosidase (ermC-lacZ) gene fusion in Escherichia coli

D R Kirsch et al. J Bacteriol. 1984 Jul.

Abstract

A fusion constructed between the putative attenuator plus the first 219 nucleotides of the ermC (erythromycin resistance) structural gene and a 5' terminally deleted lacZ gene produced a moderate, basal level of beta-galactosidase which was increased by erythromycin addition. Another construction containing an intact ermC gene in addition to the fusion produced lower levels of beta-galactosidase, suggesting that the ermC gene product exerts negative feedback control on expression.

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References

    1. J Antibiot (Tokyo). 1972 Nov;25(11):647-52 - PubMed
    1. Proc Natl Acad Sci U S A. 1974 Apr;71(4):1342-6 - PubMed
    1. Arch Roum Pathol Exp Microbiol. 1976 Jan-Jun;35(1-2):111-8 - PubMed
    1. Gene. 1977;2(2):95-113 - PubMed
    1. J Bacteriol. 1979 Jan;137(1):635-43 - PubMed