Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1984 Jul;74(1):292-5.
doi: 10.1172/JCI111414.

Intact human erythrocytes prevent hydrogen peroxide-mediated damage to isolated perfused rat lungs and cultured bovine pulmonary artery endothelial cells

K M Toth, D P Clifford, E M Berger, C W White, J E Repine

Intact human erythrocytes prevent hydrogen peroxide-mediated damage to isolated perfused rat lungs and cultured bovine pulmonary artery endothelial cells

K M Toth et al. J Clin Invest. 1984 Jul.

Abstract

Addition of untreated or glutaraldehyde-fixed human erythrocytes decreased hydrogen peroxide (H2O2)-mediated acute edematous injury in isolated rat lungs, H2O2-induced damage to cultured bovine pulmonary artery endothelial cells, and H2O2-dependent oxidation of reduced cytochrome C in vitro. The results suggest that intact erythrocytes can scavenge H2O2, and as a result, protect the lung and possibly other tissues from damage.

PubMed Disclaimer

References

    1. J Biol Chem. 1976 Apr 10;251(7):2182-5 - PubMed
    1. Am Rev Respir Dis. 1983 Sep;128(3):469-72 - PubMed
    1. J Lab Clin Med. 1967 Jul;70(1):158-69 - PubMed
    1. Am Rev Respir Dis. 1983 Sep;128(3):552-9 - PubMed
    1. Am J Pathol. 1974 Mar;74(3):507-32 - PubMed

Publication types