Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1984 Jun 25;12(12):5087-99.
doi: 10.1093/nar/12.12.5087.

Homology between two EBV early genes and HSV ribonucleotide reductase and 38K genes

T Gibson, P Stockwell, M Ginsburg, B Barrell
Comparative Study

Homology between two EBV early genes and HSV ribonucleotide reductase and 38K genes

T Gibson et al. Nucleic Acids Res. .

Abstract

Computer-matching of amino acid sequences predicted from the complete EBV DNA sequence against the known HSV gene sequences has revealed significant homology between two EBV reading frames and the HSV1 and HSV2 140K and 38K proteins which are associated with ribonucleotide reductase activity. The two genes are arranged tandemly as in HSV though it appears that, unlike HSV, the two mRNAs are not 3' co-terminal. We have mapped two promoters predicted from the DNA sequence for these genes and shown them to be transcribed at a similar stage in the virus life cycle to that of the HSV genes.

PubMed Disclaimer

References

    1. J Virol. 1972 Mar;9(3):408-18 - PubMed
    1. J Gen Virol. 1974 Sep;24(3):465-80 - PubMed
    1. J Virol. 1976 Apr;18(1):151-5 - PubMed
    1. Proc Natl Acad Sci U S A. 1977 Dec;74(12):5463-7 - PubMed
    1. Nature. 1978 Mar 23;272(5651):373-5 - PubMed

Publication types

Associated data