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. 1984 Aug 10;225(4662):634-6.
doi: 10.1126/science.6330900.

Cellular transformation by human papillomavirus DNA in vitro

S L Watts, W C Phelps, R S Ostrow, K R Zachow, A J Faras

Cellular transformation by human papillomavirus DNA in vitro

S L Watts et al. Science. .

Abstract

Molecularly cloned DNA's of human papillomaviruses HPV-5 and HPV-l induced morphological transformation of mouse C127 cells in culture. Single-cell clones of cells transformed by papillomavirus contained multiple persistent episomal copies of the transfected DNA species and were analyzed for growth characteristics indicating malignant potential.

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