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. 1984;81(1-2):171-5.
doi: 10.1007/BF01309306.

Monoclonal antibodies against BLV-transformed sheep cells. Brief report

K Hamada, M Onuma, K Tsukiyama, T Mikami, H Izawa

Monoclonal antibodies against BLV-transformed sheep cells. Brief report

K Hamada et al. Arch Virol. 1984.

Abstract

Hybrid cell lines were prepared by the fusion of BALB/c myeloma, P3X63Ag 8.653 cells with the spleen cells of BALB/c mice that were immunized with SF-28 cells, sheep fibroblasts transformed with BLV in vitro. Five clones of hybrid progeny produced cytotoxic IgG1 antibodies against SF-28 cells. The tested monoclonal antibodies showed cytotoxic activity against 4 out of 6 BLV-transformed sheep fibroblasts as well as SF-28 cells but failed to react with other cells, including BLV-producing FLK cells, bovine lymphosarcomas and normal sheep cells. These monoclonal antibodies showed suppressive effect on colony formation of SF-28 cells in soft agar culture.

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