Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1984 Aug;57(2):380-4.

Prostaglandin E2 depresses natural cytotoxicity by inhibiting interleukin-1 production by large granular lymphocytes

J Herman, A R Rabson

Prostaglandin E2 depresses natural cytotoxicity by inhibiting interleukin-1 production by large granular lymphocytes

J Herman et al. Clin Exp Immunol. 1984 Aug.

Abstract

Enriched large granular lymphocytes treated with varying concentrations of prostaglandin E2 (PGE2) for varying time periods showed considerably reduced natural cytotoxicity against K-562 target cells. The same cells when activated by lipopolysaccharide, produced substantially less interleukin-1 (IL-1) as compared to cells not treated with PGE2. It is concluded that the inhibition of natural killer (NK) cell activity produced by PGE2 is due to inhibition of IL-1 production by these cells.

PubMed Disclaimer

References

    1. J Clin Invest. 1971 Feb;50(2):442-8 - PubMed
    1. Lancet. 1975 May 31;1(7918):1218-20 - PubMed
    1. Clin Exp Immunol. 1976 Apr;24(1):42-8 - PubMed
    1. Br J Cancer. 1977 Jun;35(6):881-4 - PubMed
    1. Cell Immunol. 1978 Aug;39(1):165-77 - PubMed

MeSH terms

LinkOut - more resources