Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1984;108(2):214-20.
doi: 10.1007/BF00402469.

Leukemia induction by methylnitrosourea (MNU) in selected mouse strains. Effects of MNU on hemopoietic stem cells, the immune system and natural killer cells

H J Seidel, L Kreja
Comparative Study

Leukemia induction by methylnitrosourea (MNU) in selected mouse strains. Effects of MNU on hemopoietic stem cells, the immune system and natural killer cells

H J Seidel et al. J Cancer Res Clin Oncol. 1984.

Abstract

T cell leukemias were induced by a single dose of methylnitrosourea (MNU) in DBA/2, C57/Bl/6, NMRI, BDF1, and CBA mice. The latency period in the CBA strain was much longer than in the others. Studies on the pluripotent stem cells in the bone marrow and T cell reactions of thymus and spleen cells showed a toxicity of MNU for these parameters but no significant differences between the strains. The activity of the natural killer (NK) cells in the spleen and peritoneal exudate cells, studied also after additional stimulation by injection of Corynebacterium parvum, was influenced by MNU, but again no relation to leukemogenesis could be established. The first leukemic (transplantable) cells were found in the thymus. The presence of leukemic cells could be responsible for low NK cell activities found in BDF1 and DBA/2 mice late after MNU.

PubMed Disclaimer

References

    1. Baines P, Dexter TM, Schofield R (1979) Characterization of malignant cell populations in MNU-induced leukaemia in mice. Leuk Res 3:23–28 - PubMed
    1. Dexter TM, Schofield R, Lajtha LG, Moore M (1974) Studies on the mechanisms of chemical leukemogenesis. Br J Cancer 30:325–331 - PMC - PubMed
    1. Ehrlich R, Efrati M, With IP (1980) Cytotoxicity and cytostasis mediated by splenocytes of mice subjected to chemical carcinogens and of mice bearing primary tumors. In: Herberman RB (ed) Natural cell-mediated immunity against tumors. Academic Press, New York, pp 997–1010
    1. Fey F, Rentz E, Drescher B, Ehm I, Baumbach L, Micheel B (1980) Demonstration of C-type viruses in N-methyl-N-nitrosourea (MNU)-induced leukemia of mice by reverse transcriptase activity and XC assay. Neoplasma 27:183–186 - PubMed
    1. Frei JV (1980) Methylnitrosourea induction of thymomas in AKR mice requires one or two “hits” only. Carcinogenesis 1:721–723 - PubMed

Publication types

LinkOut - more resources